Video games/D

Da

 * Dancing Eyes: A game developed by Namco remarkably extravagant. It consists of a tiny monkey that has to surround a giantess in order to undress her.
 * Danganronpa 2: The final boss is a giant hologram version of Junko Enoshima.
 * Dante's Inferno: A hack and slash game similar to God of War. One of the bosses is Cleopatra VII Philopator, who is a giantess.
 * Dark Souls: For these epochs, it is considered one of the most difficult video games (do you know the meme "YOU DIED"?).

De

 * Demolition Girl: Riho Futaba (48 meters tall) attacks Tokyo city.

Di

 * Disney Heroes : Battle Mode: Alice (from the 1951 film) can grow giant to deal more damage and boost stats.
 * Disney Infinity 3.0: Alice (Mia Wasikowska) is featured as a playable character in this game. As a Special Move in combat, she can grow (by means of "EAT ME" cake) or shrink (via "DRINK ME" bottle).

Dr

 * Dragon Quest XI: Dora-in-Grey (an absolute giantess) is one of the bosses in the game.