Anime/D

Da

 * Darling in the Franxx: In itself, this anime is quite similar to Neon Genesis Evangelion. The mechas also have a body structure similar to that of Neon Genesis Evangelion, but the most notable difference is that the mechas of Darling in the Franxx look very feminine. On the other hand, if in one of the Evangelion endings, a giantess Rei Ayanami appears, at the end of Darling in the Franxx (episodes 23 and 24), a giantess Zero Two appears.
 * Darling in the Franxx - EP23-EP24: The Strelizia True Apus (actually she is Zero Two) takes the appearance of a large woman (like a mega-giantess or giga-giantess).

De

 * Detective Opera Milky Holmes - EP??: Arsene becomes a giantess.

Do

 * Dog Days: In season 3, The Sky Priest Farine is seen really big (absolute giantess). She even makes small avatars from her hair and various female characters interact with them (para-giantesses).
 * Don't Leave Me Alone, Daisy - EP03: Reijiro Techno's growth beam causes Daisy Hitomi Matsuzawa to grow into a giantess.
 * Doraemon: There are several episodes where Nobita is shrunk and interacts with women.

Dr

 * Dr. Slump: A gag series written and illustrated by Akira Toriyama.
 * Dr. Stone: Despite the show taking place in the distant future of the real world with no actual giantesses in the series, there is a representation of sulfuric acid as a luring goddess.
 * Dragon Ball: The masterpiece of Akira Toriyama. This article includes its sequels (Z and Super).
 * Dream Users: A team of exorcists is dedicated to fighting demons. There are a couple of episodes with GTS scenes.