Anime/S

Sa

 * Saint October - EP??:

Se

 * Seton Academy: Join the Pack: Ferryl Okami is a mini-giantess in the series.

Sh

 * Shaman King: From episode 40, the series becomes a battle of giants. However, despite several giant characters, there are only 3 giantesses: Eliza Mephisto (the most important), Kororo and Morphine.
 * Shinzo - EP26: Although she is not directly a giantess, one of the villains of this series is projected on a huge screen at the bottom of the stage, giving the feeling of being a giantess (this is a case of pseudo-giantess).
 * Shuffle! Memories - EP12: In one of the attempts to get the attention of Sia (Lisianthus), Rin (being shrunk) jumps into her body, but he "lands" between her tits.

Sp

 * Space Patrol Luluco: A comedy series about the adventures of Luluco, a young space police officer.
 * Spellbound! Magical Princess Lilpri - EP30: "The One-Inch Boy! Pri!". Issun-Boshi and his wife are transported by accident to the dimension of the Idol Lilpri along with the magic hammer of the demons which enlarges or shrinks those who are beaten with it. Issun-Boshi is small as it says in the title (it measures 1 inch).
 * Spirit of Wonder:

Ss

 * SSSS.Gridman - EP06: A giant monster (kaiju) tries to get a date with a human, taking a female human form. However, this kaiju briefly grows in size to intimidate the human.

St

 * Stitch:
 * Bojo:
 * Shrink:
 * Strange Dawn:

Su

 * Super Mario Issun-boshi - EP2: Rare animated series (anime) about Super Mario franchise combined with the Japanese story of Issun-boshi. In its second episode, Mario (shrunken) interacts with Princess Peach.

Sw

 * Sword Art Online: There are fairies para-giantess, as well as Urðr being over 3 meters tall (mini-giantess).