Dexter's Laboratory

Dexter's Laboratory was an animated American children's science fiction comedy series created by Genndy Tartakovsky for Cartoon Network.

The series revolves around Dexter, a genius kid with a secret lab filled with a collection of his inventions. Dexter is constantly in conflict with his sister Dee Dee, who always manages to enter his laboratory despite his efforts to keep her out of it, as well as Mandark his archrival.

Featured relative giantess: Dee Dee
The series does not have many main characters and the secondary ones are usually not very relevant. Therefore, the misadventures of the protagonist Dexter lives mostly with sister Dee Dee.

Dee Dee suffers all kinds of alterations to her body due to the extravagant inventions of brother, which also includes alterations in her physical size (as a perfect giantess or metamorphosed), simply interacting with beings smaller than her (para-giantess) or piloting a giant robot with an aspect similar to her.