Western animation/S

Sa

 * Sanjay and Craig: What episode(s)?
 * Sabrina: The Animated Series - EP11: It is a spin-off series from Sabrina the Teenage Witch. "Shrink to Fit". Sabrina and Chloe use magic to make themselves thin enough to wear the latest pair of skinny jeans (after Gem mocks Sabrina and Chloe for not having them and Sabrina thinks Harvey likes skinny girls thanks to a picture in his locker), but find that the spell causes the user to reduce in height as well as weight.

Sc

 * Schoolhouse Rock: Grammar - Unpack Your Adjectives: "Schoolhouse Rock" was a 1973 preschool educational series. The episode called "Grammar - Unpack Your Adjectives" features a brief scenes where a girl grows up to be a giantess and the boy shrinks.

Sh

 * SheZow - EP02a: After frustrating an attempted robbery and taking a bank note, Guy must rush to return the money before the police find out. Due to a side effect in his powers for doing bad deeds, we see the protagonist Guy Handom begin to shrink in size, being mocked by his twin sister (Kelly) and his best friend Maz.
 * Shimmer and Shine - SE3-EP20b:

Si

 * Simsala Grimm - SE3-EP01: Yoyo and Doc Croc find themselves in the classic tale of Jack and the Beanstalk. They meet the giant's wife.

Sk

 * Skysurfer Strike Force - SE1-EP05:

Sn

 * Snorks - SE2-EP09b: A siren is enlarged.

So

 * Sofia the First: Preschool series about a child princess called Sofia.
 * South Park: Satiricial comedy series about the American culture and its problems.

St

 * Star vs. the Forces of Evil: A white nordid magician teenager must live in the "normal world" and face the Forces of Evil.
 * Steven Universe: The "crystal gems" (extraterrestrial creatures with superpowers of feminine appearance, of which, the creator, Rebecca Sugar states that they have no gender) can be merged, among these fusions, there are gigantas, for example Opal, Sugilite, Malachite, Alexandrite, among others. Something curious, is that the protagonist of the series, Steven Universe, possibly is macrophile, he has shown a certain fascination for giant women, and even came to sing a song on the subject in the episode "Giant Woman".
 * Stickin' Around: A slife of life series about two children who live in their imagination.
 * Stripperella - EP08: Although the whole episode dealed the SD theme, there was hardly a brief GTS scene.

Su

 * Super Friends: A childish action series based on the DC Comics's characters.
 * Supernoobs - SE1-EP12a: The noobs try to buy a new video game. Stacy, an employee of the video game store where the players arrive, is affected by a space virus that turns her into a giant turtle/dragon (similar to Bowser in the "Super Mario Bros." franchise).