Being nice does not mean that it will not hurt the smallest, there are times when the relative giantess hurts the smallest unintentionally but without realizing it (referring to the "unaware" trope), that is, due to her excessive power (an inevitable trope).
chibiBiscuit and his wife: she is bigger than him and she treats him with remarkable kindness.
It is the same couple previously mentioned. Here she crushes him with her breasts (boobcrush). It could be the case that the pressure is hurting the tiny body of chibiBiscuit, but she does not realize it and at the same time she has no intention of hurting him.
Alex and Hitomi, another famous gentleman couple created by the artist Sugarnhoney, it is appreciated that both are semi-furry characters that represent a cat and mouse, although cats are natural predators of mice, Hitomi decides to be loving with Alex because of her strong love towards them.
Other notable clichés of the friendly giantess are the remarkable interaction between the couples, and the fact that several of the GTS community love to see the relative giantess playing in a friendly way with the small men (usually not abruptly, but carefully and tenderly).