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- Dancing Eyes: A game developed by Namco remarkably extravagant. It consists of a tiny monkey that has to surround a giantess in order to undress her.
- Danganronpa 2: The final boss is a giant hologram version of Junko Enoshima.
- Dante's Inferno: A hack and slash game similar to God of War. One of the bosses is Cleopatra VII Philopator, who is a giantess.
- Dark Souls: For these epochs, it is considered one of the most difficult video games (do you know the meme "YOU DIED"?).
- Disney Heroes : Battle Mode: Alice (from the 1951 film) can grow giant to deal more damage and boost stats.
- Disney Infinity 3.0: Alice (Mia Wasikowska) is featured as a playable character in this game. As a Special Move in combat, she can grow (by means of "EAT ME" cake) or shrink (via "DRINK ME" bottle).